Artículos científicos

 

  • Synthesis of 9,9′-[1,2-Ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6H-purin-6-one, an Impurity of Acyclovir.R.M. Suárez, M.P. Matía, J.L. Novella, A. Molina, A. Cosme,J.J. Vaquero, J. Alvarez-Builla. Molecules 2012, 17, 8735-8741.
  • Determination of nonprotein amino acids and betaines in vegetable oils by flow injection triple-quadrupole tandem Mass Spectrometry: a screening method for the detection of adulterations of olive oils. L. Sánchez-Hernández, L. Nozal, M.L. Marina, A.L. Crego, Journal of Agricultural and Food Chemistry 2012, 60, 896-903
  • Bactericidal effect of saffron (Crocus sativus L.) on Salmonella enterica during storageC. Pintado, A. de Miguel, O. Acevedo, L. Nozal, J.L. Novella, R. Rotger. Food Control 2011, 22, 638-642.
  • Microbiological quality of saffron from the main producer countries. I. Cosano, C. Pintado, O. Acevedo, J.L. Novella, G.L. Alonso, M. Carmona, C. de la Rosa, R. Rotger. Journal of Food Protection 2009, 72, 2217-2220.
  • Synthesis of {3-(2-dimethylamino-ethyl)-2-[3-(2-dimethylaminoethyl)-1H-indol-5-ylmethyl]-1H-indol-5-yl}-N-methyl-methanesulfonamide, the main Sumatriptan impurity. A.Sanz, A.M.G. Carril, M.P. Matía, J.L. Novella, J. Alvarez-Builla. Arkivoc 2008, (ii), 53-58.
  • Synthesis of -(1, 1, 3-trioxo-1, 3-dihydrobenzo[d]isothiazol-2-yl)-alkanecarboxylic acids: conventional versus microwave heating. L.Soler, V.Cerrada, M.P. Matía, J.L. Novella, J. Alvarez-Builla. Arkivoc 2007, (iv), 312-319.
  • Biodiesel and FAME synthesis assisted by microwaves:Homogeneous batch and flow processes. J. Hernando, P. Leton, M.P. Matia, J.L. Novella, J. Alvarez-Builla . Fuel 2007, 86, 1641–1644
  • Crocetin esters, picrocrocins and its related compounds present in Crocus sativus stigmas and Gardenia jasminoides fruits. tentative identification of seven new compounds by LC-ESI-MS. M.Carmona, A. Zalacain, A.M. Sanchez, J.L. Novella, G.L. Alonso. Journal agricultural and food chemistry 2006, 54, 973-979.
  • Synthesis of 2- and 4-hydroxymethyl Loratadine, usual impurities in Loratadine syrup formulations. V. Cerrada, M.P. Matía-Martín, J. L. Novella, J. Alvarez-Builla. Arkivoc 2005 (ix) 200-206
  • Synthesis of sterculic acid. J. Hernando, M.P. Matía, J.L. Novella, J. Alvarez-Builla. Arkivoc 2002, (v), 26-30.

 

DIRECTOR CIENTIFICO Y ASESORES (selección de los cinco últimos años)

  • Remote Aryl Cyanation via Isocyanide–Cyanide Rearrangement on Tosylmethyl Isocyanide Derivatives. A. Coppola, P. Sánchez-Alonso, D. Sucunza, C. Burgos, R. Alajarín, J. Alvarez-Builla, M.E.G. Mosquera, J.J. Vaquero. Org. Lett., 2013, 15 (13), 3388–3391.
  • A cascade reaction of azolopyrimidines. Synthesis of unusual indole and azaindole derivatives. M. Morón, C. Burgos, J. Alvarez-Builla, A. Salgado, M.E.G. Mosquera, J.J. Vaquero. Chem. Comm.  2012, 48, 9171-9173.
  • Two-photon absorption cross-section of Quinolizinium based dyes and their application in fluorescence microscopy of living cellsE.M.S. Maçôas, G. Marcelo, S. Pinto, T. Cañeque, A.M. Cuadro, J.J. Vaquero, J.M.G. Martinho. Chem. Comm. 2011, 47, 7374–7376.
  • Losartan-antioxidants Hybrids: Novel Molecules in the Prevention of Hypertension-Induced Cardiovascular Damage. G. García, M. Rodríguez-Puyol, R. Alajarin, I. Serrano, P. Sánchéz-Alonso, M. Griera,  J.J. Vaquero, D. Rodríguez-Puyol, J. Álvarez-Builla, M.L. Diez-Marqués. J. Med. Chem. 2009, 52, 7220–7227.
  • A Unified Approach to Quinolizinium Cations and Related Systems by Ring-closing Metathesis. A. Núñez, B. Abarca, A.M. Cuadro, J. Alvarez-Builla, J.J. VaqueroJ. Org. Chem. 2009, 74, 4166-4176.
  • Sulfonated Water-Soluble N-Heterocyclic Carbene Silver(I) Complexes: Behavior in Aqueous Medium and as NHC-Transfer Agents to Platinum(II)E.A. Baquero, G.F. Silbestri, P. Gómez-Sal, J.C. Flores, E. de Jesús. Organometallics, 2013, 32, 2814-2826.
  • Effects of cerium oxide nanoparticles to fish and mammalian cell lines: an assessment of cytotoxicity and methodology. P. Rosenkranz, M.L. Fernández-Cruz, E. Conde, M.B. Ramírez-Fernández, J.C. Flores, M. Fernández, J.M. Navas. Toxicology in Vitro, 2012, 26, 888-896.
  • Water-Soluble N-Heterocyclic Carbene Platinum(0) Complexes: Recyclable Catalysts for the Hydrosilylation of Alkynes in Water at Room Temperature. G.F. Silbestri, J.C. Flores, E. de Jesús. Organometallics, 2012, 31, 3355-3360.
  • Evaluation of new cellulose-based chiral stationary phases Sepapak-2 and Sepapak-4 for the enantiomeric separation of pesticides by nano-LC and CECV. Pérez-Fernández, E. Domínguez-Vega, B. Chankvetadze, A.L. Crego, M.A. García, M.L. Marina. Journal of Chromatography A, 2012, 1234, 22-31.
  • A capillary electrophoresis-tandem mass spectrometry methodology for the determination of non-protein amino acids in vegetable oils as novel markers for the detection of adulterations in olive oils. L. Sánchez-Hernández, M.L. Marina, A.L. Crego. Journal of Chromatography A, 2011, 1218, 4944-4951.
  • Determination of L- and D-carnitine in dietary food supplements using CE-tandem MS. L. Sánchez-Hernández, M. Castro-Puyana, C. García-Ruiz, A.L. Crego, M.L. Marina. Food Chemistry, 2010, 120, 921-928.
  • Simultaneous separation of epinephrine and norepinephrine enantiomers by EKC: application to the analysis of pharmaceutical formulations. M. Castro-Puyana, R. Drewnowska, V. Pérez-Fernández, M.A. García, A.L. Crego, M.L. Marina. Electrophoresis, 2009, 30, 2947-2954.
  • Enantiomeric separation of glycidyl tosylate by CE. Application to the study of catalytic asymmetric epoxidation of allyl alcoholS. Morante-Zarcero, A.L. Crego, I. del Hierro, I. Sierra, M.L. Marina. Electrophoresis, 2008, 29, 4575-4582.
  • Synthesis and evaluation of quinazoline derivatives as phosphodiesterase 7 inhibitors. A.I. Sanchez, V. Martinez-Barrasa, C. Burgos, J.J. Vaquero, J. Alvarez-Builla, E. Terricabras, V. Segarra. Bioorganic Medicinal Chemistry 2013, 21(8), 2370-2378.
  • New losartan-hydrocaffeic acid hybrids as antihypertensive-antioxidant dual drugs: Ester, amide and amine linkers. G. Garcia, I. Serrano, P. Sanchez-Alonso, M. Rodriguez-Puyol, R. Alajarin, M. Griera, J.J. Vaquero, D. Rodriguez-Puyol, J. Alvarez-Builla, M.L. Diez-Marques. European Journal of Medicinal Chemistry 2012, 50, 90-101.
  • Unusual Approach to 3-Aryl-2-aminopyridines through a Radical Mechanism: Synthesis and Theoretical Rationale from Quantum Mechanical Calculations. M. Camacho-Artacho, V. Abet, L.M. Frutos, F. Gago, J. Alvarez-Builla, C. Burgos. Journal of Organic Chemistry 2011, 76(5), 1452-1455.
  • Pd-catalyzed reactions on pyridinium N-heteroarylaminides. Step-by-step synthesis of 3,5-unsymmetrically disubstituted 2-aminopyridines. M. Cordoba, R. Castillo, M.L. Izquierdo, J. Alvarez-Builla. Tetrahedron 2010, 66(14), 2624-2632.
  • Pyridinium N-heteroarylaminides: synthesis of N-heteroarylpolyamines. R. Castillo, M. Cordoba, M.L. Izquierdo, J. Alvarez-Builla. Tetrahedron 2009, 65(47), 9782-9790.